Thrombotic Microangiopathies

Von Willebrand Factor-Mediated Thrombotic Microangiopathies

Pathogenesis of thrombotic microangiopathy: insights from animal models.

Animal models are important experimental tools for investigating the molecular mechanisms, environmental and genetic susceptibilities underlying the development of thrombotic microangiopathies. Large mammal, small animal models, knockout, transgenic and conditional knockout mouse models are available to investigate haemolytic uraemic syndrome, thrombotic thrombocytopenic purpura and vascular en...

Articles médicaux concernant les MAT

RECOMMANDATIONS Recommandations du cnr-mat publiées sous l'égide de la Société de Réanimation de Langue Française et de la Société Française d'Hématologie. ARTICLES EN FRANÇAIS L’activité de télémédecine dans les microangiopathies thrombotiques : un progrès dans les maladies rares nécessitant une prise en charge en urgence [Telemedicine in thrombotic microangiopathies: A way forward in rare dis...

Infection frequently triggers thrombotic microangiopathy in patients with preexisting risk factors: a single-institution experience.

Thrombotic microangiopathies are rare conditions characterized by microangiopathic hemolytic anemia, microthrombi, and multiorgan insult. The disorders, which include hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, are often acute and life threatening. We report a retrospective analysis of 65 patients presenting to our institution from 1997 to 2008 with all forms of thromboti...

Intestinal Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplantation

Endothelial Pathology in Thrombotic Microangiopathies

Introduction Thrombotic microangiopathy is a term for a morphologic lesion characterized by platelet and fibrin thrombi involving the microvasculature. The morphologic lesions thus overlap between hemolytic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP), and the lesions seen in scleroderma and malignant hypertension. HUS/TTP typically involves glomeruli and smaller vessels, whereas s...